Hillsborough County Fire Rescue responded to the “large residential structure fire” about 6:30 a.m. at 3218 Alene St., just west of Sligh Avenue and north of Lambright Street.
Flames engulfed the house, rising at least 20 feet. It took about an hour to extinguish the blaze.
There were no reports of injuries.
Because of the flames, emergency personnel could not do a check of the interior, but there did not appear to be anyone inside, Fire Rescue spokeswoman Jessica Damico said.